What, me worry? is the famous response of Alfred E. Newman of Mad Magazine. In general, you probably ought to worry.
What's going on with them? is often my response when I get curious emails or when students or colleagues seem to misread my intentions. It does not matter what's going on with them. What matter is how I respond and how I adapt to their misreadings. Can I respond to lower the temperature? Can I adapt to their needs, so that they read me correctly?
I know how to handle both of these, most parents have. But in fact lots of life is more like parenting than dealing with mature adults.